Protein kinase C isoforms in human aortic smooth muscle cells

Protein kinase C isoforms in human airway smooth muscle cells: activation of PKC-ζ during proliferation.

Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and growth. We have previously described the pattern of isoform expression of PKC in canine airway smooth muscle. This study identified the isoforms present in human cultured airway smooth muscle cells and also addressed the question of whether mitogenesis in these cells is associated with changes in a specifi...

Protein kinase C isoforms in human airway smooth muscle cells: activation of PKC-z during proliferation

Carlin, Steve, Kenny X. F. Yang, Richard Donnelly and Judith L. Black. Protein kinase C isoforms in human airway smooth muscle cells: activation of PKC-z during proliferation. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L506–L512, 1999.—Protein kinase C (PKC) is implicated in the regulation of smooth muscle contractility and growth. We have previously described the pattern of isoform exp...

Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signalling Junctions and Protein Kinase A

Protein Kinase C and Smooth Muscle Contraction

• Protein kinase C (PKC) is a family of phospholipiddependent Ca 2+ /diacylglycerol-stimulated enzymes. It is an ubiquitous protein that plays a multifunctional role in the transduction of extracellular signals activating the phospholipid turnover and generating diacylglycerol (DAG). DAG can be produced from the hydrolysis of phospatidylinositol-1,4-bisphosphate, phosphatidylcholine, or sphingo...

Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms.

Endothelin-1 (ET-1), a potent vasoconstrictor, has been implicated in the pathogenesis of coronary vasospasm by enhancing coronary vasoconstriction to vasoactive eicosanoids; however, the cellular mechanisms involved are unclear. We investigated whether physiological concentrations of ET-1 enhance coronary smooth muscle contraction to vasoactive eicosanoids by activating specific protein kinase...